Article
Fibroblast growth factors.
Genome biology - 1 Jan 2001
Ornitz D M, Itoh N
Abstract excerpt
SUMMARY: Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF family range in molecular mass from 17 to 34 kDa and share 13-71% amino acid identity. Between vertebrate species, FGFs are highly conserved in both gene structure and amino-acid sequence. FGFs have a high affinity...
Topics
- Animals
- Evolution, Molecular
- Fibroblast Growth Factors
- Gene Expression Regulation, Developmental
- Heparan Sulfate Proteoglycans
- Heparin
- Humans
- Models, Molecular
- Mutation
- Physical Chromosome Mapping
- Receptors, Fibroblast Growth Factor
- Substrate Specificity