Article
Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos.
Genes & development - 1 Aug 1998
Partanen J, Schwartz L, Rossant J
Abstract excerpt
Intercellular communication is needed for both the generation of the mesodermal germ layer and its division into distinct subpopulations. To dissect the functions of fibroblast growth factor receptor-1 (FGFR1) during mouse gastrulation as well as to gain insights into its possible roles during la...
Topics
- Alleles
- Animals
- Binding Sites
- Body Patterning
- Female
- Gene Expression Regulation, Developmental
- Genes, Dominant
- Genes, Homeobox
- In Situ Hybridization
- Limb Deformities, Congenital
- Mice
- Mice, Transgenic
- Models, Biological
- Mutagenesis, Site-Directed
- Mutation
- Phenotype
- Phosphorylation
- Pregnancy