Article
LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets.
Nucleic acids research - 1 Dec 2012
Wilm Andreas, Aw Pauline Poh Kim, Bertrand Denis, Yeo Grace Hui Ting, Ong Swee Hoe, Wong Chang Hua, Khor Chiea Chuen, Petric Rosemary, Hibberd Martin Lloyd, Nagarajan Niranjan
Abstract excerpt
The study of cell-population heterogeneity in a range of biological systems, from viruses to bacterial isolates to tumor samples, has been transformed by recent advances in sequencing throughput. While the high-coverage afforded can be used, in principle, to identify very rare variants in a population, existing ad hoc approaches frequently fail to distinguish true variants from sequencing errors. We report a...
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