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Article

CHOPER filters enable rare mutation detection in complex mutagenesis populations by next-generation sequencing.

PloS one - 1 Jan 2015

Salehi Faezeh, Baronio Roberta, Idrogo-Lam Ryan, Vu Huy, Hall Linda V, Kaiser Peter, Lathrop Richard H

Abstract excerpt

Next-generation sequencing (NGS) has revolutionized genetics and enabled the accurate identification of many genetic variants across many genomes. However, detection of biologically important low-frequency variants within genetically heterogeneous populations remains challenging, because they are difficult to distinguish from intrinsic NGS sequencing error rates. Approaches to overcome these limitations are...

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PMID: 25692681
DOI: 10.1371/journal.pone.0116877
PMCID: PMC4333345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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