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Article

DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.

Molecular and cellular biology - 1 Apr 2013

Heir Pardeep, Sufan Roxana I, Greer Samantha N, Poon Betty P, Lee Jeffrey E, Ohh Michael

Abstract excerpt

Substrate engagement by F-box proteins promotes NEDD8 modification of cullins, which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). However, the mechanism by which substrate recruitment triggers cullin neddylation remains unclear. Here, we identify DCNL1 (defective in cullin neddylation 1-like 1) as a component of CRL2 called ECV (elongins BC/CUL2/VHL) and show that molecular...

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Source

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Identifiers

PMID: 23401859
DOI: 10.1128/MCB.01342-12
PMCID: PMC3624248

Genes

CUL2
VHL
NEDD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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