Article
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009
Meyer-Schaller Nathalie, Chou Yang-Chieh, Sumara Izabela, Martin Dale D O, Kurz Thimo, Katheder Nadja, Hofmann Kay, Berthiaume Luc G, Sicheri Frank, Peter Matthias
Abstract excerpt
Cullin (Cul)-based E3 ubiquitin ligases are activated through the attachment of Nedd8 to the Cul protein. In yeast, Dcn1 (defective in Cul neddylation 1 protein) functions as a scaffold-like Nedd8 E3-ligase by interacting with its Cul substrates and the Nedd8 E2 Ubc12. Human cells express 5 Dcn1-like (DCNL) proteins each containing a C-terminal potentiating neddylation domain but distinct amino-terminal...
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