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Article

F-box-directed CRL complex assembly and regulation by the CSN and CAND1.

Molecular cell - 11 Sept 2009

Schmidt Michael W, McQuary Philip R, Wee Susan, Hofmann Kay, Wolf Dieter A

Abstract excerpt

The COP9 signalosome (CSN) is thought to maintain the stability of cullin-RING ubiquitin ligases (CRL) by limiting the autocatalytic destruction of substrate adapters such as F box proteins (FBPs). CAND1, a protein associated with unneddylated CUL1, was proposed to assist in this role in an as yet unclear fashion. We found that only a subset of Schizosaccharomyces pombe FBPs, which feature a critical F box...

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Share to CDC2 Protein Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19748355
DOI: 10.1016/j.molcel.2009.07.024
PMCID: PMC2779159

Genes

CAND1
CUL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

F-box-directed CRL complex assembly and regulation by the CSN and CAND1.PMID 19748355Read ↗

Increasing the Unneddylated Cullin1 Portion Rescues the csn Phenotypes by Stabilizing Adaptor Modules To Drive SCF Assembly.Semantic proximity Read ↗

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.Semantic proximity Read ↗

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DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptorSemantic proximity Read ↗

C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues.Semantic proximity Read ↗

The C-terminal tail of CSNAP attenuates the CSN complex.Semantic proximity Read ↗

Neurospora COP9 signalosome integrity plays major roles for hyphal growth, conidial development, and circadian function.Semantic proximity Read ↗

CIF-1, a Shared Subunit of the COP9/Signalosome and Eukaryotic Initiation Factor 3 Complexes, Regulates MEL-26 Levels in the Caenorhabditis elegans EmbryoSemantic proximity Read ↗

Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex.Semantic proximity Read ↗

The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome.Semantic proximity Read ↗

Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation.Semantic proximity Read ↗

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