Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex.

doi:10.1593/neo.06520

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Article

Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex.

Neoplasia (New York, N.Y.) - 1 Nov 2006

Sufan Roxana I, Ohh Michael

Abstract excerpt

ECV is an E3 ubiquitin ligase complex, which is composed of elongins B and C, Rbx1, Cul2, and the substrate-conferring von Hippel-Lindau (VHL) tumor-suppressor protein that targets the catalytic alpha subunit of hypoxia-inducible factor (HIF) for oxygen-dependent ubiquitin-mediated destruction. Mutations in VHL that compromise proper HIFalpha regulation through ECV have been documented in the majority of renal...

Topics

Carrier Proteins
Catalytic Domain
Cell Line
Cullin Proteins
Humans
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit
Iron-Binding Proteins
Models, Biological
Mutation
NEDD8 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxygen

Protein Binding

Protein Structure, Tertiary

Ubiquitin-Conjugating Enzymes

Ubiquitin-Protein Ligases

Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 17132228
DOI: 10.1593/neo.06520
PMCID: PMC1716018

Genes

VHL
NEDD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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