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Article

The TFIIH subunit Tfb3 regulates cullin neddylation.

Molecular cell - 5 Aug 2011

Rabut Gwenaël, Le Dez Gaëlle, Verma Rati, Makhnevych Taras, Knebel Axel, Kurz Thimo, Boone Charles, Deshaies Raymond J, Peter Matthias

Abstract excerpt

Cullin proteins are scaffolds for the assembly of multisubunit ubiquitin ligases, which ubiquitylate a large number of proteins involved in widely varying cellular functions. Multiple mechanisms cooperate to regulate cullin activity, including neddylation of their C-terminal domain. Interestingly, we found that the yeast Cul4-type cullin Rtt101 is not only neddylated but also ubiquitylated, and both modifications...

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Share to Cullin Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to SKP Cullin F-Box Protein Ligases

Share to Transcription Factor TFIIH

Share to Transcription Factors, TFII

Share to Ubiquitin-Protein Ligases

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Source

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Identifiers

PMID: 21816351
DOI: 10.1016/j.molcel.2011.05.032
PMCID: PMC3186349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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