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Article

Substrate-mediated regulation of cullin neddylation.

The Journal of biological chemistry - 8 Jun 2007

Chew Eng-Hui, Hagen Thilo

Abstract excerpt

Cullin-based E3 ligases are a large family of multi-subunit ubiquitin ligases with diverse cellular functions, including the regulation of the cell cycle, of the DNA damage response, and of various transcription factors. These ligases are composed of one of six mammalian cullin homologs (Cul1, Cul2, Cul3, Cul4a, Cul4b, and Cul5), the Ring finger containing protein Roc1/Rbx1, and cullin homolog-specific adaptor...

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Source

Identifiers

PMID: 17439941
DOI: 10.1074/jbc.M701153200

Genes

CAND1
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Substrate-mediated regulation of cullin neddylation.PMID 17439941Read ↗

DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.Semantic proximity Read ↗

DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptorSemantic proximity Read ↗

The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.Semantic proximity Read ↗

The CRL4DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.Semantic proximity Read ↗

Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex.Semantic proximity Read ↗

Neddylation-induced conformational control regulates cullin RING ligase activity in vivo.Semantic proximity Read ↗

RING finger specificity in SCF-driven protein destruction.Semantic proximity Read ↗

The TFIIH subunit Tfb3 regulates cullin neddylation.Semantic proximity Read ↗

Neddylation and CAND1 independently stimulate SCF ubiquitin ligase activity in Candida albicans.Semantic proximity Read ↗

Rbx1 flexible linker facilitates cullin-RING ligase function before neddylation and after deneddylation.Semantic proximity Read ↗

Identification of Elongin C and Skp1 sequences that determine Cullin selection.Semantic proximity Read ↗

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