Article
A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.
Molecular vision - 1 Jan 2013
Guggenheim Jeremy A, McMahon George, Kemp John P, Akhtar Saeed, St Pourcain Beate, Northstone Kate, Ring Susan M, Evans David M, Smith George Davey, Timpson Nicholas J, Williams Cathy
Abstract excerpt
PURPOSE: Corneal curvature is a key determinant of the refractive power of the eye. Variants in two genes, FKBP12-rapamycin complex-associated protein 1 (FRAP1) on chromosome 1p36.2 and platelet-derived growth factor receptor alpha (PDGFRA) on chromosome 4q12, have shown genome-wide significant association with normal variation in corneal curvature in a study of subjects of Asian origin. Variants at the PDGFRA...
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