Article
Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia.
Investigative ophthalmology & visual science - 4 Oct 2021
Plotnikov Denis, Cui Jiangtian, Clark Rosie, Wedenoja Juho, Pärssinen Olavi, Tideman J Willem L, Jonas Jost B, Wang Yaxing, Rudan Igor, Young Terri L, Mackey David A, Terry Louise, Williams Cathy, Guggenheim Jeremy A
Abstract excerpt
Purpose: Emmetropization requires coordinated scaling of the major ocular components, corneal curvature and axial length. This coordination is achieved in part through a shared set of genetic variants that regulate eye size. Poorly coordinated scaling of corneal curvature and axial length results in refractive error. We tested the hypothesis that genetic variants regulating eye size in emmetropic eyes are...
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