Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants near PDGFRA are associated with corneal curvature in Australians.

Investigative ophthalmology & visual science - 11 Oct 2012

Mishra Aniket, Yazar Seyhan, Hewitt Alex W, Mountain Jenny A, Ang Wei, Pennell Craig E, Martin Nicholas G, Montgomery Grant W, Hammond Christopher J, Young Terri L, Macgregor Stuart, Mackey David A

Abstract excerpt

PURPOSE: Irregularity in the corneal curvature (CC) is highly associated with various eye disorders such as keratoconus and myopia. The sample had limited power to find genomewide significant (5 × 10(-8)) hits but good power for replication. Thus, an attempt was made to test whether alleles in the FRAP1 and PDGFRA genes, recently found to be associated with CC in Asian populations, also influence CC in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cornea
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant, Newborn

Share to Pregnancy

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Refraction, Ocular

Share to Refractive Errors

Share to Western Australia

Source

Open in PubMed Open full text

Identifiers

PMID: 22969067
DOI: 10.1167/iovs.12-10489
PMCID: PMC3471606

Genes

PDGFRA
TRIM29

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants near PDGFRA are associated with corneal curvature in Australians.PMID 22969067Read ↗

Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.Semantic proximity Read ↗

A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.Semantic proximity Read ↗

CMPK1 and RBP3 are associated with corneal curvature in Asian populations.Semantic proximity Read ↗

Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.Semantic proximity Read ↗

Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.Semantic proximity Read ↗

Corneal curvature-associated MTOR variant differentiates mild myopia from high myopia in Han Chinese population.Semantic proximity Read ↗

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.Semantic proximity Read ↗

Association of genetic variants in PDGFRA with high myopia in the Han population of southwestern China.Semantic proximity Read ↗

A genome-wide association study of corneal astigmatism: The CREAM Consortium.Semantic proximity Read ↗

Heritability and Genetic Factors of Astigmatism and Corneal Curvature: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

Association analysis of exome variants and refraction, axial length, and corneal curvature in a European-American population.Semantic proximity Read ↗

Association of PDGFRA polymorphisms with the risk of corneal astigmatism in a Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.