Article
A genome-wide association study of corneal astigmatism: The CREAM Consortium.
Molecular vision - 1 Jan 2018
Shah Rupal L, Li Qing, Zhao Wanting, Tedja Milly S, Tideman J Willem L, Khawaja Anthony P, Fan Qiao, Yazar Seyhan, Williams Katie M, Verhoeven Virginie J M, Xie Jing, Wang Ya Xing, Hess Moritz, Nickels Stefan, Lackner Karl J, Pärssinen Olavi, Wedenoja Juho, Biino Ginevra, Concas Maria Pina, Uitterlinden André, Rivadeneira Fernando, Jaddoe Vincent W V, Hysi Pirro G, Sim Xueling, Tan Nicholas, Tham Yih-Chung, Sensaki Sonoko, Hofman Albert, Vingerling Johannes R, Jonas Jost B, Mitchell Paul, Hammond Christopher J, Höhn René, Baird Paul N, Wong Tien-Yin, Cheng Chinfsg-Yu, Teo Yik Ying, Mackey David A, Williams Cathy, Saw Seang-Mei, Klaver Caroline C W, Guggenheim Jeremy A, Bailey-Wilson Joan E
Abstract excerpt
Purpose: To identify genes and genetic markers associated with corneal astigmatism. Methods: A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Cases were defined as having >0.75 diopters of corneal astigmatism. Subsequent gene-based...
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