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Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.

Human molecular genetics - 15 Sept 2011

Han Siyu, Chen Peng, Fan Qiao, Khor Chiea-Chuen, Sim Xueling, Tay Wan-Ting, Ong Rick Twee-Hee, Suo Chen, Goh Liang-Kee, Lavanya Raghavan, Zheng Yingfeng, Wu Renyi, Seielstad Mark, Vithana Eranga, Liu Jianjun, Chia Kee-Seng, Lee Jeannette Jen-Mai, Tai E-Shyong, Wong Tien-Yin, Aung Tin, Teo Yik-Ying, Saw Seang-Mei

Abstract excerpt

Corneal curvature (CC) is a key determinant of major eye diseases, such as keratoconus, myopia and corneal astigmatism. No prior studies have discovered the genes for CC. Here we report the findings from four genome-wide association studies of CC in 10 008 samples from three population groups in Singapore. Our discovery phase surveyed 2867 Chinese and 3072 Malays, allowing us to identify two loci that were...

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Source

Identifiers

PMID: 21665993
DOI: 10.1093/hmg/ddr269

Genes

PDGFRA

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