Article
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.
Communications biology - 19 Mar 2020
Fan Qiao, Pozarickij Alfred, Tan Nicholas Y Q, Guo Xiaobo, Verhoeven Virginie J M, Vitart Veronique, Guggenheim Jeremy A, Miyake Masahiro, Tideman J Willem L, Khawaja Anthony P, Zhang Liang, MacGregor Stuart, Höhn René, Chen Peng, Biino Ginevra, Wedenoja Juho, Saffari Seyed Ehsan, Tedja Milly S, Xie Jing, Lanca Carla, Wang Ya Xing, Sahebjada Srujana, Mazur Johanna, Mirshahi Alireza, Martin Nicholas G, Yazar Seyhan, Pennell Craig E, Yap Maurice, Haarman Annechien E G, Enthoven Clair A, Polling JanRoelof, Hewitt Alex W, Jaddoe Vincent W V, van Duijn Cornelia M, Hayward Caroline, Polasek Ozren, Tai E-Shyong, Yoshikatsu Hosoda, Hysi Pirro G, Young Terri L, Tsujikawa Akitaka, Wang Jie Jing, Mitchell Paul, Pfeiffer Norbert, Pärssinen Olavi, Foster Paul J, Fossarello Maurizio, Yip Shea Ping, Williams Cathy, Hammond Christopher J, Jonas Jost B, He Mingguang, Mackey David A, Wong Tien-Yin, Klaver Caroline C W, Saw Seang-Mei, Baird Paul N, Cheng Ching-Yu
Abstract excerpt
Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in 44,042 individuals of Caucasian and Asian with replication in 88,218 UK Biobank data. We identified 47 loci (of which 26 are novel), with population-specific signals as well as shared...
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