Article
A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries.
Human molecular genetics - 15 Jan 2012
Li Xiaohui, Bykhovskaya Yelena, Haritunians Talin, Siscovick David, Aldave Anthony, Szczotka-Flynn Loretta, Iyengar Sudha K, Rotter Jerome I, Taylor Kent D, Rabinowitz Yaron S
Abstract excerpt
Keratoconus is a condition in which the cornea progressively thins over time, and is a major cause for cornea transplantation. To identify keratoconus susceptibility regions, we performed a comprehensive genome-wide association study (GWAS) using a discovery and replication design. A discovery panel of 222 keratoconus Caucasian patients and 3324 Caucasian controls was genotyped using Illumina 370K beadchips....
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