Article

A cytomegalovirus immunevasin triggers integrated stress response-dependent reorganization of the endoplasmic reticulum

2019-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Human cytomegalovirus (HCMV) encodes an ER-resident glycoprotein, UL148, which activates the unfolded protein response (UPR) but is fully dispensable for viral replication in cultured cells. Hence, its previously ascribed roles in immune evasion and modulation of viral cell tropism are hypothesized to cause ER stress. Here, we show that UL148 is necessary and sufficient to drive the formation of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a643ee7f-dbe4-5f1d-b87d-10311d02b6e5
DOI: 10.1101/641068

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A cytomegalovirus immunevasin triggers integrated stress response-dependent reorganization of the endoplasmic reticulumDOI 10.1101/641068Read

The Human Cytomegalovirus Nonstructural Glycoprotein UL148 Reorganizes the Endoplasmic ReticulumSemantic proximity Read

ER reorganization and intracellular retention of CD58 are functionally independent properties of the human cytomegalovirus ER resident glycoprotein UL148Semantic proximity Read

The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein ResponseSemantic proximity Read

Viral mediated tethering to SEL1L facilitates ER-associated degradation of IRE1Semantic proximity Read

Herpes Simplex Virus 1 UL34 Protein Regulates the Global Architecture of the Endoplasmic Reticulum in Infected Cells.Semantic proximity Read

Identification of Human Cytomegalovirus Genes Important for Biogenesis of the Cytoplasmic Virion Assembly ComplexSemantic proximity Read

Virion Proteomics of Genetically Intact HCMV Reveals a Novel Regulator of Envelope Glycoprotein Composition that Protects Against Humoral ImmunitySemantic proximity Read

Infection-Induced Changes Within the Endocytic Recycling Compartment Suggest a Roadmap of Human Cytomegalovirus EgressSemantic proximity Read

The endoplasmic reticulum stress response in disease pathogenesis and pathophysiologySemantic proximity Read

Spatial Relationships between Markers for Secretory and Endosomal Machinery in Human Cytomegalovirus-Infected Cells versus Those in Uninfected CellsSemantic proximity Read

Typical Stress Granule Proteins Interact with the 3′ Untranslated Region of Enterovirus D68 To Inhibit Viral ReplicationSemantic proximity Read

Human cytomegalovirus induces neuronal gene expression for viral maturationSemantic proximity Read