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Article

Membrane chaperone Shr3 assists in folding amino acid permeases preventing precocious ERAD.

The Journal of cell biology - 26 Feb 2007

Kota Jhansi, Gilstring C Fredrik, Ljungdahl Per O

Abstract excerpt

The yeast endoplasmic reticulum (ER) membrane-localized chaperone Shr3 plays a critical role in enabling amino acid permeases (AAPs) to fold and attain proper structures required for functional expression at the plasma membrane. In the absence of Shr3, AAPs specifically accumulate in the ER, where despite the correct insertion of their 12 transmembrane segments (TMSs), they aggregate forming large molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17325204
DOI: 10.1083/jcb.200612100
PMCID: PMC2064020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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