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Article

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.

The EMBO journal - 3 May 2006

Cursi Silvia, Rufini Alessandra, Stagni Venturina, Condò Ivano, Matafora Vittoria, Bachi Angela, Bonifazi Antonio Paniccià, Coppola Luigi, Superti-Furga Giulio, Testi Roberto, Barilà Daniela

Abstract excerpt

We identified Caspase-8 as a new substrate for Src kinase. Phosphorylation occurs on Tyr380, situated in the linker region between the large and the small subunits of human Procaspase-8, and results in downregulation of Caspase-8 proapoptotic function. Src activation triggers Caspase-8 phosphorylation on Tyr380 and impairs Fas-induced apoptosis. Accordingly, Src failed to protect Caspase-8-defective human cells...

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Identifiers

PMID: 16619028
DOI: 10.1038/sj.emboj.7601085
PMCID: PMC1456929

Genes

EGF

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