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Article

Dissociation of the subunits of the calcium-independent receptor of alpha-latrotoxin as a result of two-step proteolysis.

Biochemistry - 14 Apr 2009

Krasnoperov Valery, Deyev Igor E, Serova Oxana V, Xu Chongfeng, Lu Yun, Buryanovsky Leonid, Gabibov Alexander G, Neubert Thomas A, Petrenko Alexander G

Abstract excerpt

CIRL (the calcium-independent receptor of alpha-latrotoxin), a neuronal cell surface receptor implicated in the regulation of exocytosis, is a member of the GPS family of chimeric cell adhesion/G protein-coupled receptors. The predominant form of CIRL is a membrane-bound complex of two subunits, p120 and p85. Extracellularly oriented p120 contains hydrophilic cell adhesion domains, whereas p85 is a heptahelical...

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Identifiers

PMID: 19161337
DOI: 10.1021/bi802163p
PMCID: PMC2682192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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