Article
Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients.
Journal of the American Heart Association - 9 Mar 2018
Singh Sonal, McDonough Caitrin W, Gong Yan, Alghamdi Wael A, Arwood Meghan J, Bargal Salma A, Dumeny Leanne, Li Wen-Yi, Mehanna Mai, Stockard Bradley, Yang Guang, de Oliveira Felipe A, Fredette Natalie C, Shahin Mohamed H, Bailey Kent R, Beitelshees Amber L, Boerwinkle Eric, Chapman Arlene B, Gums John G, Turner Stephen T, Cooper-DeHoff Rhonda M, Johnson Julie A
Abstract excerpt
BACKGROUND: Thiazide and thiazide-like diuretics are first-line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with incompletely understood mechanisms. Our goal was to identify genomic variants associated with thiazide-like diuretic/chlorthalidone-induced glucose change. METHODS AND...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.