Article
Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate.
PloS one - 1 Jan 2012
Aslibekyan Stella, Goodarzi Mark O, Frazier-Wood Alexis C, Yan Xiaofei, Irvin Marguerite R, Kim Eric, Tiwari Hemant K, Guo Xiuqing, Straka Robert J, Taylor Kent D, Tsai Michael Y, Hopkins Paul N, Korenman Stanley G, Borecki Ingrid B, Chen Yii-Der I, Ordovas Jose M, Rotter Jerome I, Arnett Donna K
Abstract excerpt
A recent large-scale meta-analysis of genome-wide studies has identified 95 loci, 59 of them novel, as statistically significant predictors of blood lipid traits; we tested whether the same loci explain the observed heterogeneity in response to lipid-lowering therapy with fenofibrate. Using data from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN, n = 861) we fit linear mixed models with the genetic...
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