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Article

An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.

Molecular psychiatry - 1 Mar 2014

Arey R N, Enwright J F, Spencer S M, Falcon E, Ozburn A R, Ghose S, Tamminga C, McClung C A

Abstract excerpt

Mice with a mutation in the Clock gene (ClockΔ19) have been identified as a model of mania; however, the mechanisms that underlie this phenotype, and the changes in the brain that are necessary for lithium's effectiveness on these mice remain unclear. Here, we find that cholecystokinin (Cck) is a direct transcriptional target of CLOCK and levels of Cck are reduced in the ventral tegmental area (VTA) of ClockΔ19...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23399917
DOI: 10.1038/mp.2013.12
PMCID: PMC3783638

Genes

CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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