Article
Role for the Clock gene in bipolar disorder.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2007
McClung C A
Abstract excerpt
Nearly all patients with bipolar disorder have severely disrupted circadian rhythms. Treatment with mood stabilizers can restore these daily rhythms, and this is correlated with patient recovery. However, it is still uncertain whether clock abnormalities are the cause of bipolar disorder or if these rhythm disruptions are secondary to alterations in other circuits. Furthermore, the mechanism by which the...
Topics
- ARNTL Transcription Factors
- Affect
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Bipolar Disorder
- Brain
- CLOCK Proteins
- Circadian Rhythm
- Humans
- Mice
- Mutation
- Suprachiasmatic Nucleus