Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Stringency of Start Codon Selection in the Filamentous Fungus Neurospora crassa

9 Feb 2013

Abstract excerpt

In eukaryotic cells initiation may occur from near-cognate codons that differ from AUG by a single nucleotide. The stringency of start codon selection impacts the efficiency of initiation at near-cognate codons and the efficiency of initiation at AUG codons in different contexts. We used a codon-optimized firefly luciferase reporter initiated with AUG or each of the nine near-cognate codons in preferred context...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics and Phylogenetic Studies
Share to Microbial Natural Products and Biosynthesis
Share to RNA and protein synthesis mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23396971
DOI: 10.1074/jbc.m112.447177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Stringency of Start Codon Selection in the Filamentous Fungus Neurospora crassaPMID 23396971Read ↗

Diversity of preferred nucleotide sequences around the translation initiation codon in eukaryote genomes.Semantic proximity Read ↗

Translation Initiation Fidelity Defective Mutations in eIF5 and eIF2β Show Distinct Sensitivity to the Sequence Context for Recognition of the UUG Start Codon.Semantic proximity Read ↗

Hidden stop codons orchestrate mRNA fate by ambushing ribosomal frameshifting associated with codon usageSemantic proximity Read ↗

Quantitative global studies reveal differential translational control by start codon context across the fungal kingdomSemantic proximity Read ↗

Selection on start codons in prokaryotes and potential compensatory nucleotide substitutions.Semantic proximity Read ↗

AUG codons at the beginning of protein coding sequences are frequent in eukaryotic mRNAs with a suboptimal start codon context.Semantic proximity Read ↗

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read ↗

Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery.Semantic proximity Read ↗

IF2 and unique features of initiator tRNAfMet help establish the translational reading frame.Semantic proximity Read ↗

Mammalian Alternative Translation Initiation Is Mostly Nonadaptive.Semantic proximity Read ↗

Principles of start codon recognition in eukaryotic translation initiation.Semantic proximity Read ↗

Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.