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Article

Translation Initiation Fidelity Defective Mutations in eIF5 and eIF2β Show Distinct Sensitivity to the Sequence Context for Recognition of the UUG Start Codon.

Biochemical genetics - 1 Aug 2026

Ram Anup Kumar, Kole Tanaya, Alone Pankaj V

Abstract excerpt

In Saccharomyces cerevisiae, the AUG codon typically signals translation initiation to set an open reading frame, with a preference for the A- 3AA/U- 1(AUG)U+ 4 sequence context. The mutant eIF5G31R or eIF2βS264Y proteins cause translation initiation fidelity defect by initiating translation at a near cognate UUG codon, in addition to the AUG start codon (suppressor of initiation codon; Sui¯ phenotype). However,...

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PMID: 41460464
DOI: 10.1007/s10528-025-11312-y
PMCID: PMC13388412

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