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Article

Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom

20 Jan 2020

Abstract excerpt

Eukaryotic protein synthesis generally initiates at a start codon defined by an AUG and its surrounding Kozak sequence context, but the quantitative importance of this context in different species is unclear. We tested this concept in two pathogenic Cryptococcus yeast species by genome-wide mapping of translation and of mRNA 5' and 3' ends. We observed thousands of AUG-initiated upstream open reading frames...

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PMID: 32020195
DOI: 10.1093/nar/gkaa060

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