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Article

Selection on start codons in prokaryotes and potential compensatory nucleotide substitutions.

Scientific reports - 29 Sept 2017

Belinky Frida, Rogozin Igor B, Koonin Eugene V

Abstract excerpt

Reconstruction of the evolution of start codons in 36 groups of closely related bacterial and archaeal genomes reveals purifying selection affecting AUG codons. The AUG starts are replaced by GUG and especially UUG significantly less frequently than expected under the neutral expectation derived from the frequencies of the respective nucleotide triplet substitutions in non-coding regions and in 4-fold degenerate...

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Identifiers

PMID: 28963504
DOI: 10.1038/s41598-017-12619-6
PMCID: PMC5622118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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