Article
Association of AMP-activated protein kinase with risk and progression of non-Hodgkin lymphoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2013
Hoffman Aaron E, Demanelis Kathryn, Fu Alan, Zheng Tongzhang, Zhu Yong
Abstract excerpt
BACKGROUND: Metabolic dysregulation has been identified as an "emerging hallmark" of cancer. The heterotrimeric AMP-activated protein kinase (AMPK) complex is a central regulator of the metabolic system and an important component of the mTOR pathway and the p53 axis, making it uniquely positioned to influence carcinogenesis through its canonical functions in the metabolic arena, as well as through more...
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