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Combined analysis of polymorphism variants in hMTH1, hOGG1 and MUTYH genes on the risk of type 2 diabetes in the Chinese population.

Gene - 25 Apr 2013

Cao Lili, Zhou Wei, Zhu Yanbei, Guo Wenwen, Cai Zhenming, He Xuan, Xie Yuan, Li Xinxiu, Zhu Dalong, Wang Yaping

Abstract excerpt

Reactive oxygen species are considered to play a role in the development of type 2 diabetes mellitus (T2DM) and its complications. 8-Oxoguanine, which is one of the major oxidation base lesions produced by reactive oxygen species, may cause G:C to T:A transversion mutations because it can mispair with adenine. hMTH1 (human mutT homolog 1), hOGG1 (human 8-oxoguanine glycosylase 1) and MUTYH (human mutY homolog)...

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Identifiers

PMID: 23396182
DOI: 10.1016/j.gene.2013.01.053

Genes

MUTYH

Variants

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