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AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population.

Molecular and cellular endocrinology - 30 Jan 2011

Chen Huimei, Sun Caixia, Guo Wenwen, Meng Ran, Du Hong, Qi Qiufeng, Gu Xin, Li Lirong, Zhang Kui, Zhu Dalong, Wang Yaping

Abstract excerpt

The Mutyh DNA glycosylase is involved in the repair of oxidized DNA bases. Because oxidative stress may contribute to increased diabetes risk, the common variant of the MUTYH gene (AluYb8MUTYH) was investigated for its possible role in type 2 diabetes mellitus (T2DM). A total of 565 T2DM patients and 565 healthy subjects from China were enrolled in a case-control study. The distribution of AluYb8MUTYH differed in...

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Source

Identifiers

PMID: 21112374
DOI: 10.1016/j.mce.2010.11.021

Genes

MUTYH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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