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Article

Association between polymorphisms of the DNA base excision repair genes MUTYH and hOGG1 and age-related macular degeneration.

Experimental eye research - 1 May 2012

Synowiec Ewelina, Blasiak Janusz, Zaras Malgorzata, Szaflik Jerzy, Szaflik Jacek P

Abstract excerpt

Age-Related Macular Degeneration (AMD) is an eye disease that results in progressive and irreversible loss of central vision and is considered as the primary cause of visual impairment, including blindness, in the elderly in industrialized countries. Oxidative stress has been implicated in the pathogenesis of AMD. The hOGG1 and the MUTYH genes play an important role in the repair of oxidatively damaged DNA in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22469746
DOI: 10.1016/j.exer.2012.02.008

Genes

MUTYH

Variants

rs1052133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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