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Article

Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.

Carcinogenesis - 1 Jun 2013

Wei Qiou, Jiang Hong, Baker Alyson, Dodge Lisa K, Gerard Matthieu, Young Matthew R, Toledano Michel B, Colburn Nancy H

Abstract excerpt

Sulfiredoxin (Srx) is the enzyme that reduces the hyperoxidized inactive form of peroxiredoxins. To study the function of Srx in carcinogenesis in vivo, we tested whether loss of Srx protects mice from cancer development. Srx null mice were generated and colon carcinogenesis was induced by an azoxymethane (AOM) and dextran sulfate sodium (DSS) protocol. Compared with either wild-type (Wt) or heterozygotes,...

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Source

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Identifiers

PMID: 23393226
DOI: 10.1093/carcin/bgt059
PMCID: PMC3670259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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