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Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases.

Cancer research - 15 Oct 2006

Lee Dong-Hyun, Esworthy R Steven, Chu Christy, Pfeifer Gerd P, Chu Fong-Fong

Abstract excerpt

Mice deficient in two glutathione peroxidases (GPX), Gpx1 and Gpx2, [Gpx1/2-double knockout (DKO) mice] are prone to ileocolitis on a mixed C57BL/6 and 129S1/SvJ (B6.129) genetic background. We reported previously that approximately 25% of B6.129 Gpx1/2-DKO mice develop ileocolonic tumors by 6 to 9 months of age, when their non-DKO littermates [having at least one wild-type (WT) Gpx1 or Gpx2 allele] rarely have...

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PMID: 17047045
DOI: 10.1158/0008-5472.CAN-06-0732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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