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Inactivation of glutathione S -transferase alpha 4 blocks Enterococcus faecalis -induced bystander effect by promoting macrophage ferroptosis

16 Jan 2025

Abstract excerpt

Enterococcus faecalis-infected macrophages produce 4-hydroxynonenal (4-HNE) that mediates microbiota-induced bystander effect (MIBE) leading to colorectal cancer (CRC). Glutathione S-transferase alpha 4 (Gsta4), a specific detoxifying enzyme for 4-HNE, is overexpressed in human CRC and E. faecalis-induced murine CRC. However, the roles of Gsta4 in E. faecalis-induced colitis and CRC remain unclear. Herein, we...

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PMID: 39819335
DOI: 10.1080/19490976.2025.2451090

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