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Article

AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.

Human molecular genetics - 15 May 2013

Haskin Joseph, Szargel Raymonde, Shani Vered, Mekies Lucy N, Rott Ruth, Lim Grace G Y, Lim Kah-Leong, Bandopadhyay Rina, Wolosker Herman, Engelender Simone

Abstract excerpt

Parkin E3 ubiquitin-ligase activity and its role in mitochondria homeostasis are thought to play a role in Parkinson's disease (PD). We now report that AF-6 is a novel parkin interacting protein that modulates parkin ubiquitin-ligase activity and mitochondrial roles. Parkin interacts with the AF-6 PDZ region through its C-terminus. This leads to ubiquitination of cytosolic AF-6 and its degradation by the...

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Identifiers

PMID: 23393160
DOI: 10.1093/hmg/ddt058
PMCID: PMC3803144

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.PMID 23393160Read ↗

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