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Article

Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration.

Human molecular genetics - 15 Apr 2013

Sul Jee-Won, Park Min-Young, Shin Juhee, Kim Young-Ran, Yoo Sung-Eun, Kong Young-Yun, Kwon Ki-Sun, Lee Young Ho, Kim Eunhee

Abstract excerpt

This study reports the physical and functional interplay between Fas-associated factor 1 (FAF1), a death-promoting protein, and parkin, a key susceptibility protein for Parkinson's disease (PD). We found that parkin acts as an E3 ubiquitin ligase to ubiquitinate FAF1 both in vitro and at cellular level, identifying FAF1 as a direct substrate of parkin. The loss of parkin function due to PD-linked mutations was...

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Source

Identifiers

PMID: 23307929
DOI: 10.1093/hmg/ddt006

Genes

FAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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