Article
Parkin stabilizes PINK1 through direct interaction.
Biochemical and biophysical research communications - 5 Jun 2009
Shiba Kahori, Arai Takeo, Sato Shigeto, Kubo Shin-ichiro, Ohba Yusuke, Mizuno Yoshikuni, Hattori Nobutaka
Abstract excerpt
Parkinson disease (PD) is the most common movement disorder and is characterized by dopaminergic dysfunction. The majority of PD cases are sporadic; however, the discovery of genes linked to rare familial forms of the disease has provided crucial insight into the molecular mechanisms of disease pathogenesis. Multiple genes mediating familial forms of Parkinson's disease (PD) have been identified, such as parkin...
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