Article

Peroxiredoxin 6 Modulates Mitochondrial Function and Mitophagy in PINK1-Deficient Cells Under Oxidative Stress

2025-12-08

Abstract excerpt

Mitochondrial dysfunction and impaired mitophagy are hallmark features of Parkinson’s disease (PD), especially in patients with mutations in the PINK1 gene. Peroxiredoxin 6 (Prx6) is a bifunctional antioxidant enzyme known for its protective roles under oxidative stress, but its effects on mitochondrial dynamics and mitophagy remain poorly understood. In this study, we investigated the impact of recombinant Prx6 o...

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Literature Corpus work: c16d2fb6-21fe-534e-af95-9ab8761ed5c2
DOI: 10.20944/preprints202512.0617.v1

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