Article
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy.
The Journal of cell biology - 17 May 2010
Lee Joo-Yong, Nagano Yoshito, Taylor J Paul, Lim Kah Leong, Yao Tso-Pang
Abstract excerpt
Mutations in parkin, a ubiquitin ligase, cause early-onset familial Parkinson's disease (AR-JP). How parkin suppresses parkinsonism remains unknown. Parkin was recently shown to promote the clearance of impaired mitochondria by autophagy, termed mitophagy. Here, we show that parkin promotes mitop...
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