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Article

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2013

Chung Ji-Yun, Park Hee Ra, Lee Su-Jin, Lee Sun-Hye, Kim Jin Sik, Jung Youn-Sang, Hwang Sang Hyun, Ha Nam-Chul, Seol Won-Gi, Lee Jaewon, Park Bum-Joon

Abstract excerpt

Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD...

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Source

Identifiers

PMID: 23608757
DOI: 10.1038/labinvest.2013.60

Genes

TRAF2
TRAF6
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.PMID 23608757Read ↗

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Therapeutic potential of Parkin and its regulation in Parkinson's disease.Semantic proximity Read ↗

TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brainsSemantic proximity Read ↗

Parkin: much more than a simple ubiquitin ligase.Semantic proximity Read ↗

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling.Semantic proximity Read ↗

AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.Semantic proximity Read ↗

The PARK2 Mutation Associated with Parkinson's Disease Enhances the Vulnerability of Peripheral Blood Lymphocytes to Paraquat.Semantic proximity Read ↗

Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration.Semantic proximity Read ↗

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.Semantic proximity Read ↗

Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair.Semantic proximity Read ↗

Transcriptional alterations in skin fibroblasts from Parkinson's disease patients with parkin mutations.Semantic proximity Read ↗

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