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Article

Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit.

Molecular bioSystems - 1 May 2013

Ban Yeon Hee, Lee Jong Hyun, Gu Gyo Rim, Lee Boram, Mo SangJoon, Kwon Ho Jeong, Yoon Yeo Joon

Abstract excerpt

A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of Streptomyces sp. KCTC 11604BP fkbO deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined.

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Identifiers

PMID: 23223556
DOI: 10.1039/c2mb25419k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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