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Enhancement of FK506 production by engineering secondary pathways of <i>Streptomyces tsukubaensis</i> and exogenous feeding strategies

18 Jun 2013

Abstract excerpt

FK506 is a clinically important macrocyclic polyketide with immunosuppressive activity produced by Streptomyces tsukubaensis. However, the low titer at which it is produced is a bottleneck to its application and use in industrial processes. We have overexpressed five potential targets associated with FK506 production (fkbO, fkbL, fkbP, fkbM, fkbD) which were identified in our previous study, with the aim to...

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PMID: 23779221
DOI: 10.1007/s10295-013-1301-7

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