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Enhancement of FK520 production in Streptomyces hygroscopicus var. ascomyceticus ATCC 14891 by overpressing the pathyway specific regulatory gene fkbR2

2024-12-13

Abstract excerpt

<title>Abstract</title> <p>Ascomycin (FK520) is a 23-membered macrolide antibiotic primarily produced by the <italic>Streptomyces</italic> <italic>hygroscopicus</italic> subsp. ascomycetoides. Structurally similar to tacrolimus and rapamycin, it serves as an effective immunosuppressant widely used in the treatment of rejection reactions following organ transplantation and certain autoimmune diseases. Currently, F...

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Literature Corpus work
ed66fb84-236e-5d0e-ba12-27527440bdb5
DOI
10.21203/rs.3.rs-5074358/v1
Open publication

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Enhancement of FK520 production in Streptomyces hygroscopicus var. ascomyceticus ATCC 14891 by overpressing the pathyway specific regulatory gene fkbR2DOI 10.21203/rs.3.rs-5074358/v1
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