Article
Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1.
Gastroenterology - 1 May 2013
Yang Ling, Inokuchi Sayaka, Roh Yoon Seok, Song Jingyi, Loomba Rohit, Park Eek Joong, Seki Ekihiro
Abstract excerpt
BACKGROUND & AIMS: Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is activated in different cytokine signaling pathways. Deletion of Tak1 from hepatocytes results in spontaneous development of hepatocellular carcinoma (HCC), liver inflammation, and fibrosis. TGF-β activates TAK1 and Smad signaling, which regulate cell death, proliferation, and carcinogenesis. However, it is not clear whether TGF-β...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.