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Article

Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage.

Gastroenterology - 1 Aug 2008

Dooley Steven, Hamzavi Jafar, Ciuclan Loredana, Godoy Patricio, Ilkavets Iryna, Ehnert Sabrina, Ueberham Elke, Gebhardt Rolf, Kanzler Stephan, Geier Andreas, Breitkopf Katja, Weng Honglei, Mertens Peter R

Abstract excerpt

BACKGROUND & AIMS: The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are believed to contribute to increased rates of apoptosis. METHODS: Primary hepatocyte outgrowths and AML12 cells were used as an in vitro model to detect TGF-beta effects on the cellular phenotype and expression...

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PMID: 18602923
DOI: 10.1053/j.gastro.2008.04.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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