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Article

Bak deficiency inhibits liver carcinogenesis: a causal link between apoptosis and carcinogenesis.

Journal of hepatology - 1 Jul 2012

Hikita Hayato, Kodama Takahiro, Shimizu Satoshi, Li Wei, Shigekawa Minoru, Tanaka Satoshi, Hosui Atsushi, Miyagi Takuya, Tatsumi Tomohide, Kanto Tatsuya, Hiramatsu Naoki, Morii Eiichi, Hayashi Norio, Takehara Tetsuo

Abstract excerpt

BACKGROUND & AIMS: Hepatocyte apoptosis is a key feature of chronic liver disease including viral hepatitis and steatohepatitis. A previous study demonstrated that absence of the Bcl-2 family protein Mcl-1 led to increased hepatocyte apoptosis and development of liver tumors in mice. Since Mcl-1...

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PMID: 22414765
DOI: 10.1016/j.jhep.2012.01.027

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22414765-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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