Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.

G3 (Bethesda, Md.) - 1 Feb 2013

Shtessel Ludmila, Lowden Mia Rochelle, Cheng Chen, Simon Matt, Wang Kyle, Ahmed Shawn

Abstract excerpt

Telomeres are composed of simple tandem DNA repeats that protect the ends of linear chromosomes from replicative erosion or inappropriate DNA damage response mechanisms. The mammalian Protection Of Telomeres (POT1) protein interacts with single-stranded telomeric DNA and can exert positive and negative effects on telomere length. Of four distinct POT1 homologs in the roundworm Caenorhabditis elegans, deficiency...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luminescent Proteins

Share to Red Fluorescent Protein

Share to Telomerase

Share to Telomere

Share to Telomere-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23390606
DOI: 10.1534/g3.112.004440
PMCID: PMC3564990

Genes

POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.PMID 23390606Read ↗

The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1Semantic proximity Read ↗

The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.Semantic proximity Read ↗

Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths.Semantic proximity Read ↗

Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability.Semantic proximity Read ↗

POT-1 telomere binding protein promotes a novel form of Transgenerational Epigenetic InheritanceSemantic proximity Read ↗

Missing women—revisitedSemantic proximity Read ↗

Pot1 inactivation leads to rampant telomere resection and loss in one cell cycle.Semantic proximity Read ↗

POT1 mutations cause differential effects on telomere length leading to opposing disease phenotypes.Semantic proximity Read ↗

trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.Semantic proximity Read ↗

Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection.Semantic proximity Read ↗

POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhangSemantic proximity Read ↗

Distinct functions of POT1 at telomeres.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.