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Article

trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.

PLoS genetics - 1 Feb 2006

Meier Bettina, Clejan Iuval, Liu Yan, Lowden Mia, Gartner Anton, Hodgkin Jonathan, Ahmed Shawn

Abstract excerpt

Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but eventually become sterile as a consequence of telomere erosion and end-to-end chromosome fusions. Telomere erosion and uncapping do not cause an increase in apoptosis in the germlines of trt-1 mutants. Instead, late-generation trt-1 mutants display chromosome segregation defects that are...

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Identifiers

PMID: 16477310
DOI: 10.1371/journal.pgen.0020018
PMCID: PMC1361356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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